Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 12 0.0 0.577 0.141 0.152
biological_process el 12 0.321 0.91 0.69 0.183
biological_process ka 12 0.0 0.613 0.129 0.164
biological_process rf 12 0.0 0.577 0.141 0.152
cellular_component ct 1 0.001 0.001 0.001 0.0
cellular_component el 1 0.572 0.572 0.572 0.0
cellular_component ka 1 0.004 0.004 0.004 0.0
cellular_component rf 1 0.002 0.002 0.002 0.0
disease ct 4 0.002 0.67 0.171 0.288
disease el 4 0.005 0.038 0.024 0.012
disease ka 4 0.0 0.688 0.178 0.295
disease rf 4 0.002 0.67 0.171 0.288
genetic_interaction ct 8 0.016 0.88 0.454 0.317
genetic_interaction el 8 0.009 0.885 0.459 0.321
genetic_interaction ka 8 0.041 0.197 0.132 0.051
genetic_interaction rf 8 0.016 0.88 0.454 0.317
molecular_function ct 3 0.0 0.744 0.375 0.304
molecular_function el 3 0.009 0.744 0.409 0.304
molecular_function ka 3 0.0 0.761 0.37 0.311
molecular_function rf 3 0.0 0.744 0.375 0.304
pathway ct 3 0.06 0.226 0.137 0.068
pathway el 3 0.002 0.169 0.103 0.073
pathway ka 3 0.002 0.14 0.066 0.057
pathway rf 3 0.042 0.176 0.098 0.057
phenotype ct 5 0.002 0.204 0.084 0.092
phenotype el 5 0.248 0.563 0.397 0.126
phenotype ka 5 0.001 0.191 0.099 0.082
phenotype rf 5 0.002 0.204 0.085 0.092
protein_interaction ct 12 0.0 0.349 0.067 0.108
protein_interaction el 12 0.0 0.39 0.058 0.107
protein_interaction ka 12 0.0 0.032 0.006 0.009
protein_interaction rf 12 0.0 0.325 0.065 0.104

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 12 0.0 0.705 0.255 0.218
integration_mean_by_presence el 12 0.001 0.52 0.131 0.161
integration_mean_by_presence ka 12 0.0 0.503 0.175 0.16
integration_mean_by_presence rf 12 0.001 0.507 0.099 0.16
mean ct 12 0.0 0.593 0.248 0.206
mean el 12 0.0 0.496 0.142 0.173
mean ka 12 0.0 0.542 0.157 0.173
mean rf 12 0.0 0.518 0.099 0.162

CDF plots of non integrated kernels

CDF plots of integrated kernels